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Abstract #0519

Characterization of rat spinal cord vasoreactivity using arterial spins labelling at 9.4 T

Mohamed Tachrount 1 , Andrew Davies 2 , Roshni Desai 2 , Kenneth Smith 2 , David Thomas 1 , and Xavier Golay 1

1 UCL Institute of Neurology, London, London, United Kingdom, 2 Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom

For the first time, the feasibility of measuring vasoreactive changes in SCBF to a carbogen challenge in healthy rats was shown. Different areas of the spinal cord show different reactivity with a high degree of reproducibility. These preliminary results highlight the potential of the developed technique in the investigation of the pathogenesis of neuroinflammatory diseases such as Multiple Sclerosis.

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