Meeting Banner
Abstract #0525

TMPRSS2:ERG gene fusion and ERG overexpression in human prostate cancer are associated with changed metabolism

Ailin Falkmo Hansen 1 , Elise Sandsmark 1 , Morten Beck Rye 2,3 , Alan Wright 4 , Helena Bertilsson 2,5 , Anna M. Bofin 6 , Anders Angelsen 1 , Tone Frost Bathen 1 , and May-Britt Tessem 1,3

1 Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, 2 Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway, 3 St. Olavs Hospital, Trondheim, Norway, 4 Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 5 Department of Urology, St. Olavs Hospital, Trondheim, Norway, 6 Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

TMPRSS2-driven overexpression of ERG has been shown to be associated with several markers for prostate cancer aggressiveness, although its clinical significance is not fully understood. The aim of this study was to investigate metabolic alterations associated with ERG overexpression/TMPRSS2:ERG to increase the biological understanding of TMPRSS2:ERG fusion in prostate cancer patients. Prostate tissue samples (n=95) and prostate biopsy samples (n=40) were analyzed by 1H HR-MAS MRS. In ERG-high samples, citrate and spermine were significantly decreased compared to ERG-low samples. These results were validated in biopsy samples by FISH-detected TMPRSS2:ERG and suggest altered citrate and spermine metabolism due to ERG overexpression/TMPRSS2:ERG.

This abstract and the presentation materials are available to members only; a login is required.

Join Here