Abstract #0526
Reduced production of hyperpolarized 5-13C-glutamate is associated with the IDH1 mutation
Jose Luis Izquierdo Garcia 1 , Pavithra Luis Viswanath 1 , Pia Eriksson 1 , Marina Radoul 1 , Larry Cai 1 , Myriam M Chaumeil 1 , Russell O Pieper 2 , Joanna J Phillips 2 , and Sabrina M Ronen 1
1
University California San Francisco, San
Francisco, California, United States,
2
Department
of Neurological Surgery, Helen Diller Research Center,
University California San Francisco, San Francisco,
California, United States
This study investigated the role that mutant IDH1-driven
metabolic reprogramming plays in tumorigenesis. We
investigated hyperpolarized 5-13C-glutamate production
from hyperpolarized 2-13C-pyruvate in mutant and
wild-type cells and found that glutamate production was
significantly reduced in mutant cells, associated with a
drop in PDH activity. Treatment with dichloroacetate, a
PDH agonist, significantly increased HP 5-13C-glutamate
production with an accompanying decrease in
clonogenicity. Our results indicate that HP
5-13C-glutamate can serve as a metabolic imaging
biomarker of PDH down-regulation in IDH1 mutant glioma
cells.
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