Abstract #0527
Tumor invasion visualized by neurochemical profile modification in human GBM induced by cancer stem cells in mice: 1 H-MRS longitudinal study
Mor Mishkovsky 1 , Cristina Cudalbu 2 , Irene Vassallo 3 , Marie-France Hamou 3 , Arnaud Comment 4 , Monika Hegi 3 , and Rolf Gruetter 1,2
1
Laboratory of Functional and Metabolic
Imaging, Ecole Polytechnique Fdrale de Lausanne
(EPFL), Lausanne, Switzerland,
2
Center
of biomedical imaging (CIBM), Ecole Polytechnique
Fdrale de Lausanne (EPFL), Lausanne, Switzerland,
3
Laboratory
of Brain Tumor Biology and Genetics, Department of
Neurosurgery, Lausanne University Hospital, Lausanne,
Switzerland,
4
Institute
of the Physics of Biological Systems, Ecole
Polytechnique Fdrale de Lausanne (EPFL), Lausanne,
Switzerland
In vivo
1
H
MRS at high fields is a powerful tool able to assess the
concentration of about 20 metabolites implicated in
different cellular functions. Longitudinal studies on
cerebral diseases involving modifications in the
metabolites concentrations are routinely applied given
the non invasiveness of the technique. The present study
examines changes in the neurochemical profile after
injection of the highly invasive human glioma derived
sphere lines. Our results suggest that longitudinal
comparison of modifications in the metabolic profiles of
different brain regions allows studying the kinetics of
tumor invasion
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