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Abstract #0527

Tumor invasion visualized by neurochemical profile modification in human GBM induced by cancer stem cells in mice: 1 H-MRS longitudinal study

Mor Mishkovsky 1 , Cristina Cudalbu 2 , Irene Vassallo 3 , Marie-France Hamou 3 , Arnaud Comment 4 , Monika Hegi 3 , and Rolf Gruetter 1,2

1 Laboratory of Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland, 2 Center of biomedical imaging (CIBM), Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland, 3 Laboratory of Brain Tumor Biology and Genetics, Department of Neurosurgery, Lausanne University Hospital, Lausanne, Switzerland, 4 Institute of the Physics of Biological Systems, Ecole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland

In vivo 1 H MRS at high fields is a powerful tool able to assess the concentration of about 20 metabolites implicated in different cellular functions. Longitudinal studies on cerebral diseases involving modifications in the metabolites concentrations are routinely applied given the non invasiveness of the technique. The present study examines changes in the neurochemical profile after injection of the highly invasive human glioma derived sphere lines. Our results suggest that longitudinal comparison of modifications in the metabolic profiles of different brain regions allows studying the kinetics of tumor invasion

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