Abstract #0532
Separation of arterial and portal blood supply to mouse liver and tumour tissue using pseudo-Continuous Arterial Spin Labelling (pCASL)
Rajiv Ramasawmy 1 , Jack Anthony Wells 1 , Magdalena Sokolska 2 , James A. Meakin 3 , Sean Peter Johnson 1 , Adrienne E. Campbell-Washburn 4 , Rosamund Barbara Pedley 5 , Mark Francis Lythgoe 1 , and Simon Walker-Samuel 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
United Kingdom,
2
Institute
of Neurology, University College London, London, Greater
London, United Kingdom,
3
Oxford
University, Oxfordshire, United Kingdom,
4
National
Heart Lung and Blood Institute, National Institutes of
Health, Maryland, United States,
5
Cancer
Institute, University College London, London, Greater
London, United Kingdom
Liver perfusion measurements could be used to monitor
hepatic disease progression and therapy in pre-clinical
models. This study investigated the feasibility of using
pseudo-continuous ASL (pCASL) to measure mouse liver
perfusion, in which both the portal venous and arterial
supply to the liver were separately tagged: the mean
ratio of perfusion estimates agreed well with the
expected vascular contributions. Finally, the technique
was applied to a mouse model of liver metastasis, which
showed tumours to be exclusively arterially supplied.
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