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Abstract #0532

Separation of arterial and portal blood supply to mouse liver and tumour tissue using pseudo-Continuous Arterial Spin Labelling (pCASL)

Rajiv Ramasawmy 1 , Jack Anthony Wells 1 , Magdalena Sokolska 2 , James A. Meakin 3 , Sean Peter Johnson 1 , Adrienne E. Campbell-Washburn 4 , Rosamund Barbara Pedley 5 , Mark Francis Lythgoe 1 , and Simon Walker-Samuel 1

1 Centre for Advanced Biomedical Imaging, University College London, London, Greater London, United Kingdom, 2 Institute of Neurology, University College London, London, Greater London, United Kingdom, 3 Oxford University, Oxfordshire, United Kingdom, 4 National Heart Lung and Blood Institute, National Institutes of Health, Maryland, United States, 5 Cancer Institute, University College London, London, Greater London, United Kingdom

Liver perfusion measurements could be used to monitor hepatic disease progression and therapy in pre-clinical models. This study investigated the feasibility of using pseudo-continuous ASL (pCASL) to measure mouse liver perfusion, in which both the portal venous and arterial supply to the liver were separately tagged: the mean ratio of perfusion estimates agreed well with the expected vascular contributions. Finally, the technique was applied to a mouse model of liver metastasis, which showed tumours to be exclusively arterially supplied.

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