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Abstract #0534

Non-Contrast Pulmonary Perfusion using pseudo-Continuous Arterial Spin Labeling of the Inferior Vena Cava

Joshua S. Greer 1,2 , Yue Zhang 2 , Ivan Pedrosa 2,3 , and Ananth J. Madhuranthakam 2,3

1 Bioengineering, UT Dallas, Dallas, TX, United States, 2 Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 3 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Recently, pseudo-continuous ASL (pCASL) has been successfully applied to study cerebral and renal perfusion by labeling the carotid arteries and abdominal aorta. The high blood velocity in these anatomies enabled high labeling efficiency. However, the extension of pCASL to study pulmonary perfusion has been non-trivial due to the complex anatomy of the lungs. In this work, we demonstrate pulmonary perfusion using pCASL, specifically targeting the inferior vena cava and optimizing the labeling parameters to achieve high labeling efficiency. This provided higher SNR, reduced pulmonary vasculature signal and more homogeneous perfusion compared to the established pulsed ASL approach (e.g. 2D FAIRER).

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