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Abstract #0541

Arterial spin labeling in exercising calf muscle with prospective motion correction

Cline Giraudeau 1,2 , Benjamin R. Knowles 3 , Thomas Lange 3 , Michael Herbst 3,4 , Maxim Zaitsev 3 , and Pierre Carlier 1,2

1 NMR Laboratory, Institute of Myology, Paris, France, 2 NMR Laboratory, CEA, I2BM, MIRCen, Fontenay-aux-Roses, France, 3 Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 4 John A. Burns School of Medicine, Uni Hawaii, Honolulu, Hawaii, United States

Acquiring clean ASL perfusion data in exercising skeletal muscle is highly desirable and would have significant impact for the pathophysiological mechanisms of many conditions affecting the skeletal muscle, primarily or secondarily. However, studies have been limited to post-exercise data due to motion that dramatically impairs perfusion curves. Recently, real-time prospective motion correction (PMC) with optical tracking has been proposed for brain and knee MRI. In this work we investigated the potential of PMC-augmented ASL to improve the quality of perfusion curves acquired during calf muscle exercise.

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