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Abstract #0540

Large intramuscular vessel artifact in ASL: effect on calf muscle perfusion measurements and a velocity-selective solution

Jeff L Zhang 1 , Christopher J Hanrahan 1 , Jason Mendes 1 , Gwenael Layec 2 , Corey Hart 2 , Kristi Carlston 1 , Michelle Mueller 3 , Russell S Richardson 2 , and Vivian S Lee 1

1 Radiology, University of Utah, Salt Lake City, Utah, United States, 2 Division of Geriatrics, University of Utah, Utah, United States, 3 Vascular Surgery, University of Utah, Utah, United States

Capable of measuring perfusion rapidly, ASL is suitable for monitoring muscle perfusion during exercise recovery. However, ASL estimated perfusion could be severely erroneous for tissue voxels containing large blood vessels. Inclusion of large-vessel voxels in a muscle ROI could change the magnitude and the temporal pattern of the averaged perfusion dramatically. In this study, we studied ASL signals of blood vessel simulated by a flow phantom, and using the obtained velocity-perfusion relationship, developed a velocity selective method for excluding the large-vessel voxels. The method was shown to be effective for our healthy subjects, and improved the perfusion accuracy.

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