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Abstract #0539

Feasibility and Repeatability of Human Brown Adipose Tissue Volume and Perfusion Activity Using MRI

Weiying Dai 1 , Lauren S. Weiner 2 , David C. Alsop 1 , and Aaron M. Cypess 2

1 Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States, 2 2Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA, United States

Brown adipose tissue (BAT) can improve insulin sensitivity and hence may prove to be an important anti-diabetic tissue. The volume and activity of BAT have previously been measured using 18F-FDG PET/CT. Here, we demonstrate the feasibility and repeatability of using Dixon water/fat imaging and ASL imaging to assess BAT volume and perfusion responses to mild cold stimulation in the cervical area of adult humans. The Dixon method can provide a quantitative measurement of the BAT volume. ASL shows great promise for measuring perfusion activity within BAT and can be successful if the vessel signals near the BAT are well suppressed.

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