Abstract #0560
Self-gated dynamic contrast enhanced (DCE) MRI with compressed sensing acceleration to quantify permeability in the aortic root of atherosclerotic mice
Claudia Calcagno 1 , Chiara Giannarelli 2 , Abdallah G Motaal 3 , Matthias Nahrendorf 4 , Willem JM Mulder 5,6 , Zahi A Fayad 1 , and Gustav J Strijkers 3
1
Department of Radiology, Icahn School of
Medicine at Mount Sinai, New York, NY, United States,
2
Department
of Cardiology, Icahn School of Medicine at Mount Sinai,
New York, NY, United States,
3
Department
of Biomedical Engineering and Physics, Academic Medical
Center, Amsterdam, The Netherlands, Netherlands,
4
Center
for Systems Biology, Massachusetts General Hospital,
Boston, Massachusetts, United States,
5
Icahn
School of Medicine at Mount Sinai, New York, NY, United
States,
6
Department
of Radiology, Academic Medical Center, Amsterdam, The
Netherlands, Netherlands
Enhanced endothelial permeability is a hallmark of
atherosclerotic plaques at high risk for causing severe
clinical events. Here we present a method to quantify
plaque permeability in the aortic root of ApoE -/- mice,
using self-gated DCE-MRI with compressed sensing
acceleration.
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