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Abstract #0561

Large coverage HOmologous Black-Bright blood Interleaved imaging sequence (LaHOBBI) for 3D dynamic contrast enhanced MRI of vessel wall

Haikun Qi 1 , Shuo Chen 1 , Zechen Zhou 1 , Jinnan Wang 2 , Peter Koken 3 , Niranjan Balu 4 , and Huijun Chen 1

1 Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, Beijing, China, 2 Philips Research North America, Briarcliff Manor, New York, United States, 3 Innovative Technologies, Research Laboratories, Philips Technologies GmbH, Hamburg, Germany, 4 Radiology, University of Washington, Seattle, WA, United States

Dynamic contrast enhanced (DCE) MRI is important in quantifying inflammatory features of atherosclerotic plaque, and interleaved black-bright imaging technique is essential for quantitative vessel wall DCE analysis. In this study, a Large coverage HOmologous black-bright blood Interleaved imaging sequence (LaHOBBI) for vessel wall DCE MRI was proposed. The feasibility of the conducting the proposed sequence was demonstrated by in vivo experiment on carotid. The LaHOBBI sequence enables 3D large coverage, high spatial resolution vessel wall DCE imaging and 2D high temporal bright blood imaging for accurate AIF extraction, which ensures the quantitative DCE analysis and coverage of atherosclerotic plaque.

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