Quantitative ADC Mapping using DESS with Decreased T1 and Noise Sensitivity

Early disease detection of osteoarthritis is important for treatment development and much research has recently been devoted to developing imaging methods to that end. The Double Echo Steady State (DESS) sequence has been shown to be able to provide measurements of T2 and ADC in articular cartilage, which can be used as biomarkers for disease detection, in addition to morphological information. In this work, we demonstrate the ability to use the two later echoes of two DESS scans for diffusion contrast, and how the variability of the ADC estimate will depend on spoiler strength.

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