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Abstract #0597

BOLD calibration with interleaved susceptometry-based oximetry

Zachary B Rodgers 1 , Erin K Englund 2 , Maria A Fernandez-Seara 3 , and Felix W Wehrli 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, 3 Neuroimaging Laboratory, Center for Applied Medical Research, University of Navarra, Pamplona, Navarra, Spain

We present a new approach for calibrated BOLD fMRI in which BOLD and CBF are measured alongside direct quantification of global venous oxygen saturation (Y v ) via susceptometry-based oximetry. The proposed method allows for determination of M, the BOLD calibration factor, without assumptions regarding the CMRO 2 or flow changes associated with the stimulus. Three subjects completed a hypercapnic gas mixture breathing paradigm, with M-values generated from the proposed Y v -based method in agreement with the traditional Davis model. In one subject, similar M-values were generated from hyperoxia, without the usual requirement of end-tidal O 2 monitoring or the need to assume baseline Y v .

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