Abstract #0597
BOLD calibration with interleaved susceptometry-based oximetry
Zachary B Rodgers 1 , Erin K Englund 2 , Maria A Fernandez-Seara 3 , and Felix W Wehrli 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Department
of Bioengineering, University of Pennsylvania,
Philadelphia, PA, United States,
3
Neuroimaging
Laboratory, Center for Applied Medical Research,
University of Navarra, Pamplona, Navarra, Spain
We present a new approach for calibrated BOLD fMRI in
which BOLD and CBF are measured alongside direct
quantification of global venous oxygen saturation (Y
v
)
via susceptometry-based oximetry. The proposed method
allows for determination of M, the BOLD calibration
factor, without assumptions regarding the CMRO
2
or
flow changes associated with the stimulus. Three
subjects completed a hypercapnic gas mixture breathing
paradigm, with M-values generated from the proposed Y
v
-based
method in agreement with the traditional Davis model. In
one subject, similar M-values were generated from
hyperoxia, without the usual requirement of end-tidal O
2
monitoring
or the need to assume baseline Y
v
.
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