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Abstract #0598

Multimodal Validation of Physiological MRI: Triple Oxygen PET and NIRS

Daniel Bulte 1 , Hannah Hare 1 , Nazneen Sudhan 2 , Joanna Simpson 2 , Joseph Donnelly 2 , Xiuyun Liu 2 , and Jonathan Coles 2

1 FMRIB, University of Oxford, Oxford, Oxfordshire, United Kingdom, 2 WBIC, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

A dual-gas calibrated MRI paradigm designed to measure multiple cerebrovascular parameters was directly compared in 15 healthy subjects to triple oxygen PET and NIRS cerebral oximetry. CBF measures from pCASL and 15-O PET were found to be well correlated. A weak correlation was found between MRI OEF and 15-O PET OEF, but no correlation was found with NIRS OEF and either of the other modalities.

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