Abstract #0599
Measurement of -Opioid Receptor Driven Neurovascular Coupling Signals using Simultaneous PET/MRI
Hsiao-Ying Wey 1 , Jacob M Hooker 1 , Michael S. Placzek 1,2 , Bruce R Rosen 1 , and Joseph B Mandeville 1
1
A. A. Martinos Center, Department of
Radiology, Massachusetts General Hospital, Harvard
Medical School, Charlestown, MA, United States,
2
McLean
Hospital, Harvard Medical School, Belmont, MA, United
States
In this study, we present simultaneous PET/MRI study
with pharmacological (μ-opioid receptor antagonist and
agonist) challenges in nonhuman primates to determine
the relationship between opioid receptor occupancy,
dopamine modulation, and changes in CBV. PET and CBV
signals show dose-dependent reductions to opioid
antagonist challenges. PET and fMRI demonstrated
concurrent and overlapping changes in the basal
forebrain; however, the largest occupancy changes (PET)
were observed in the thalamus and caudate, while the
largest CBV changes were observed in the putamen. Taken
together with the μ-opioid agonist challenge results,
our data suggest that opioid-evoked a dopaminergic
component in the measured fMRI signal.
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