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Abstract #0599

Measurement of -Opioid Receptor Driven Neurovascular Coupling Signals using Simultaneous PET/MRI

Hsiao-Ying Wey 1 , Jacob M Hooker 1 , Michael S. Placzek 1,2 , Bruce R Rosen 1 , and Joseph B Mandeville 1

1 A. A. Martinos Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 2 McLean Hospital, Harvard Medical School, Belmont, MA, United States

In this study, we present simultaneous PET/MRI study with pharmacological (μ-opioid receptor antagonist and agonist) challenges in nonhuman primates to determine the relationship between opioid receptor occupancy, dopamine modulation, and changes in CBV. PET and CBV signals show dose-dependent reductions to opioid antagonist challenges. PET and fMRI demonstrated concurrent and overlapping changes in the basal forebrain; however, the largest occupancy changes (PET) were observed in the thalamus and caudate, while the largest CBV changes were observed in the putamen. Taken together with the μ-opioid agonist challenge results, our data suggest that opioid-evoked a dopaminergic component in the measured fMRI signal.

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