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Abstract #0605

Dynamic-Contrast-Enhanced MRI and Dynamic Tensor Imaging (DTI) for the Early Detection of Anti-angiogenic Effect and Vessel Normalization in Human Breast Cancer Treated with Neoadjuvant Chemotherapy

Thian Ng 1,2 , Bo Zhang 3 , Dennis Cheong 4 , Limiao Jiang 5 , Bingwen Zheng 6 , and Soo Chin Lee 7

1 National University of Singapore, S'pore, Singapore, Singapore, 2 CIRC/A*STAR, S'pore, Singapore, Singapore, 3 CIRC/A*STAR, Singapore, Singapore, 4 CIRC/A*STAR, S'pore, Singapore, 5 NUS/CIRC, S'pore, Singapore, 6 NUS/NERI, S'pore, Singapore, 7 NUS, S'pore, Singapore

This is a clinical trial study on advanced breast carcinoma using low-dose Sunitinib to 'Normalization' the microvascular environment to enhance the delivery of anti-cancer drugs (AC)to the cancer cells. In vivo DCE-MRI and DTI are used to monitor the perfusion,and 4 other vessel parameters changes prior to the main course of chemotherapy to reveal the most sensitive biomarker(s)with respect to tumor mass by MRI. Other histological parameters are measured.

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