Abstract #0612
Noninvasive assessment of functional tumor microvasculature and drug delivery associated with angiotensin receptor blockade in pancreatic cancer
Vidhya Kumar 1,2 , Yves Boucher 3 , Diego Ferreira 1 , Hao Liu 3 , Rakesh Jain 3 , and Alexander R Guimaraes 1,4
1
Radiology, Martinos Center for Biomedical
Imaging, Charlestown, MA, United States,
2
The
Ohio State University, Columbus, OH, United States,
3
Radiation
Oncology/Steele Lab for Tumor Biology, Massachusetts
General Hospital, Charlestown, MA, United States,
4
Radiology,
Oregon Health Sciences University, Portland, OR, United
States
MRI using FDA approved magnetic nanoparticles allows a
robust steady state technique that unlike intravital and
confocal microscopy, is readily translatable to humans
and scalable from mice to humans. The aim of this study
was to develop and apply MRI based methods at
interrogating tumor microvasculature in an established
orthotopic pancreatic cancer model, and assess if
angiotensin receptor blockade demonstrates quantificable
changes in tumor microvasculature in addition to changes
in drug delivery as measured by 18F-5fluorouracil.
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