Meeting Banner
Abstract #0612

Noninvasive assessment of functional tumor microvasculature and drug delivery associated with angiotensin receptor blockade in pancreatic cancer

Vidhya Kumar 1,2 , Yves Boucher 3 , Diego Ferreira 1 , Hao Liu 3 , Rakesh Jain 3 , and Alexander R Guimaraes 1,4

1 Radiology, Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 The Ohio State University, Columbus, OH, United States, 3 Radiation Oncology/Steele Lab for Tumor Biology, Massachusetts General Hospital, Charlestown, MA, United States, 4 Radiology, Oregon Health Sciences University, Portland, OR, United States

MRI using FDA approved magnetic nanoparticles allows a robust steady state technique that unlike intravital and confocal microscopy, is readily translatable to humans and scalable from mice to humans. The aim of this study was to develop and apply MRI based methods at interrogating tumor microvasculature in an established orthotopic pancreatic cancer model, and assess if angiotensin receptor blockade demonstrates quantificable changes in tumor microvasculature in addition to changes in drug delivery as measured by 18F-5fluorouracil.

This abstract and the presentation materials are available to members only; a login is required.

Join Here