Abstract #0613
Resolving Cellular Specific Microarchitectures Using Double Pulsed Field Gradient Weighted, Relaxation-Enhanced Magnetic Resonance Spectroscopy
Noam Shemesh 1 , Jens T Rosenberg 2,3 , Jean-Nicolas Dumez 4 , Lucio Frydman 2,5 , and Samuel C Grant 2,3
1
Champalimaud Neuroscience Programme,
Champalimaud Centre for the Unknown, Lisbon, Portugal,
2
National
High Magnetic Field Laboratory, Florida State
University, Tallahassee, FL, United States,
3
Chemical
& Biomedical Engineering, Florida State University,
Tallahassee, FL, United States,
4
Institut
de Chimie des Substances Naturelles, CNRS, UPR2301, Gif-sur-Yvette,
France,
5
Chemical
Physics, Weizmann Institute of Science, Rehovot, Israel
Cellular-specific microarchitectures are altered with
neurodegeneration and neuroplasticity, yet their
characterization remains elusive, especially because
most diffusion MR techniques rely on ubiquitous water
signals. Here, we present a methodology capable of
depicting cellular-specific microarchitectures in vivo.
We employ Relaxation Enhanced 1H MRS at 21.1 T, and
selectively target N-Acetylaspartate and myo-Inositol
resonances as markers for neurons and astrocytes,
respectively. When coupled with a double Pulsed Field
Gradient filter, RE-MRS provides the sensitivity
required for characterization of cellular-specific
morphologies. Randomly oriented cell processes were
selectively detected. These findings provide a framework
for future characterizations of diseased and healthy
tissues.
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