Abstract #0614
Single-Shot Diffusion Tensor Spectroscopic Imaging in Human Brain
Stefan Posse 1,2 , Kevin F Tagne 3 , and Stephen R Dager 4
1
Neurology, U New Mexico, Albquerque, NM,
United States,
2
Physics
and Astronomy, U New Mexico, Albuquerque, NM, United
States,
3
Neurology,
U New Mexico, Albuquerque, NM, United States,
4
Radiology,
U Washington, Seattle, WA, United States
Diffusion tensor spectroscopic imaging (DTSI) in human
brain provides intracellular markers for studying axonal
development and neurological disorders. To address the
strong motion sensitivity of existing phase encoded DTSI
we developed single-shot narrow-bandwidth
proton-echo-planar-spectroscopic-imaging with
cardiac-gating and navigator correction. Data acquired
in healthy volunteers demonstrate feasibility of mapping
the tensor of water and the ADC of metabolites across an
entire slice. The ADCs of tissue water, Cho, Cr and NAA
were consistent with previous studies using single voxel
measurements. Residual sensitivity to rotational motion
that impacts mapping of the diffusion tensor of
metabolites and navigator-based solutions will be
discussed.
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