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Abstract #0614

Single-Shot Diffusion Tensor Spectroscopic Imaging in Human Brain

Stefan Posse 1,2 , Kevin F Tagne 3 , and Stephen R Dager 4

1 Neurology, U New Mexico, Albquerque, NM, United States, 2 Physics and Astronomy, U New Mexico, Albuquerque, NM, United States, 3 Neurology, U New Mexico, Albuquerque, NM, United States, 4 Radiology, U Washington, Seattle, WA, United States

Diffusion tensor spectroscopic imaging (DTSI) in human brain provides intracellular markers for studying axonal development and neurological disorders. To address the strong motion sensitivity of existing phase encoded DTSI we developed single-shot narrow-bandwidth proton-echo-planar-spectroscopic-imaging with cardiac-gating and navigator correction. Data acquired in healthy volunteers demonstrate feasibility of mapping the tensor of water and the ADC of metabolites across an entire slice. The ADCs of tissue water, Cho, Cr and NAA were consistent with previous studies using single voxel measurements. Residual sensitivity to rotational motion that impacts mapping of the diffusion tensor of metabolites and navigator-based solutions will be discussed.

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