Quantification of mean cell size and intracellular volume fraction using temporal diffusion spectroscopy

Oscillating gradient spin echo (OGSE) methods have been used previously to probe variations in tissues at cellular and subcellular scales, but their ability to accurately measure larger cell sizes (e.g. than 10 μm) is limited. Pulse gradient spin echo (PGSE) acquisitions use long diffusion times and sample the low frequency region of temporal diffusion spectra. Combinations of OGSE and PGSE acquisitions can sample a larger region of temporal diffusion spectra over a broader range of diffusion times than any single method on its own, and hence allow an accurate quantification of intracellular volume fractions and relatively large mean cell sizes.

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