Probing metabolite diffusion at ultra-short diffusion times in the mouse brain using optimized oscillating gradients and a short echo time strategy

Measuring diffusion at ultra-short td may yield information about short-range obstacles and cytosol viscosity. However, reaching such td usually requires oscillating gradients, which in turn imply long echo times TE. Here we propose a new kind of stretched oscillating gradients that allow increasing b while preserving spectral and temporal properties of the gradient modulation. We then use these optimized gradients to measure metabolite diffusion in the mouse brain down to td=1 ms while keeping TE relatively short. The strong macromolecule signal can be used as an internal reference of null diffusivity, allowing us to discard spectra corrupted by motion artifacts.

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