Abstract #0617
Diffusion-weighted spectroscopy of N-acetylaspartate: a novel technique to specifically explore neuroaxonal damage in multiple sclerosis
Francesca Branzoli 1,2 , Benedetta Bodini 1,2 , Romain Valabrgue 1,2 , Itamar Ronen 3 , Daniel Garcia-Lorenzo 1,2 , Bruno Stankoff 1,2 , and Stephane Lehricy 1,2
1
Institut du Cerveau et de la Moelle pinire
ICM, Centre de Neuroimagerie de Recherche CENIR,
Paris, France,
2
Sorbonnes
Universit, Universit Pierre et Marie Curie and Inserm
UMR-S1127; CNRS, UMR 7225, Paris, France,
3
C.
J. Gorter Center for High Field MRI, Department of
Radiology, Leiden University Medical Center, Leiden,
Netherlands, Netherlands
Neuroaxonal degeneration is thought to play a major role
in determining permanent disability in patients with
multiple sclerosis. Diffusion-weighted MR spectroscopy
offers the unique opportunity to investigate in vivo the
diffusivity of N-acetylaspartate (NAA), which is
considered to be a specific marker for axonal
degeneration. Here, we provide our preliminary results
on the comparison between the diffusion properties of
water, NAA, total creatine and choline compounds
measured in the normal appearing white matter (NAWM) of
patients with multiple sclerosis and in the WM of
aged-matched healthy controls . We found a decrease in
ADC(NAA) in patients' normal-appearing white matter,
which reflects the microstructural alterations resulting
from the presence of axonopathy outside visible lesions.
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