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Abstract #0617

Diffusion-weighted spectroscopy of N-acetylaspartate: a novel technique to specifically explore neuroaxonal damage in multiple sclerosis

Francesca Branzoli 1,2 , Benedetta Bodini 1,2 , Romain Valabrgue 1,2 , Itamar Ronen 3 , Daniel Garcia-Lorenzo 1,2 , Bruno Stankoff 1,2 , and Stephane Lehricy 1,2

1 Institut du Cerveau et de la Moelle pinire ICM, Centre de Neuroimagerie de Recherche CENIR, Paris, France, 2 Sorbonnes Universit, Universit Pierre et Marie Curie and Inserm UMR-S1127; CNRS, UMR 7225, Paris, France, 3 C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, Netherlands

Neuroaxonal degeneration is thought to play a major role in determining permanent disability in patients with multiple sclerosis. Diffusion-weighted MR spectroscopy offers the unique opportunity to investigate in vivo the diffusivity of N-acetylaspartate (NAA), which is considered to be a specific marker for axonal degeneration. Here, we provide our preliminary results on the comparison between the diffusion properties of water, NAA, total creatine and choline compounds measured in the normal appearing white matter (NAWM) of patients with multiple sclerosis and in the WM of aged-matched healthy controls . We found a decrease in ADC(NAA) in patients' normal-appearing white matter, which reflects the microstructural alterations resulting from the presence of axonopathy outside visible lesions.

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