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Abstract #0618

Separating water and olefinic fat peaks using diffusion-weighted MRS and diffusion constraint fitting to measure vertebral bone marrow fat unsaturation

Stefan Ruschke 1 , Michael Dieckmeyer 1 , Hendrik Kooijman 2 , Axel Haase 3 , Ernst J. Rummeny 1 , Jan S. Bauer 4 , Thomas Baum 1 , and Dimitrios C. Karampinos 1

1 Department of Diagnostic and Interventional Radiology, Technische Universitt Mnchen, Munich, Bayern, Germany, 2 Philips Healthcare, Hamburg, Hamburg, Germany, 3 Zentralinstitut fr Medizintechnik, Technische Universitt Mnchen, Garching, Bayern, Germany, 4 Neuroradiology, Technische Universitt Mnchen, Munich, Bayern, Germany

Bone marrow fat composition has been attracting significant attention due to its connection to bone health. Vertebral bone marrow fat unsaturation has been traditionally quantified relying on the olefinic fat peak in the spectrum from a single-voxel short-TE MRS experiment. However, the broad peaks in the vertebral bone marrow MR spectrum and the presence of a strong water peak next to the olefinic peak can hinder a reliable extraction of the olefinic fat peak. The present work proposes a diffusion-weighted MRS experiment to extract the olefinic fat peak relying on the large difference in the diffusion coefficient between water and fat using a diffusion constraint fitting routine.

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