Towards a refined bi-compartmental model of brain metabolism using bonded cumomers analysis of 13 C MRS spectra
Brice Tiret 1,2 , Vincent Lebon 1,2 , Julien Valette 1,2 , and Pierre-Gilles Henry 3
URA 2210, Fontenay-aux-Roses, France,
Minneapolis, MN, United States
C MRS together with labeled substrate
infusion is a minimally invasive technique used to probe
the TCA cycle. Despite previous efforts, traditional
models fail to explain individual isotopomer (or more
precisely, bonded cumomers) dynamics. Using a rapid
model screening method, it becomes possible to use
previously untapped information given by bonded cumomers
to improve the bi-compartmental model. Such improvements
include adding a vesicular glutamate pool and a double
dilution of labeled plasmatic pyruvate.
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