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Abstract #0624

8-channel double tuned 13 C- 1 H transceiver phased array for 13 C MRS in human brain at 7T

Guillaume Donati 1 , Ozlem Ipek 2 , Eulalia Sers Roig 1 , and Rolf Gruetter 1,3

1 Laboratory of Functional and Metabolic Imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 2 Centre d'Imagerie Biomdicale, cole Polytechnique Fdrale de Lausanne, Lausanne, Vaud, Switzerland, 3 Department of Radiology, Universities of Lausanne and Geneva, Lausanne, Geneva, Switzerland

The main drawback of 13 C-MRS is the low sensitivity, which makes 13 C detection difficult. In addition, the 13 C- 1 H hetero-nuclear J coupling necessitates double-tuned 13 C- 1 H coils for proton decoupling during 13 C signal acquisition. Array coils provide a high sensitivity over a large field-of-view. In this study, a four channel 13 C-four channel 1 H transceiver array coil for direct 13 C-MRS in human brain at 7T was built. EM simulations show a fourfold improvement of B 1 + /√SAR 10g,max compared to a linear 13 C-quadrature 1 H coil. 1 H-decoupled 13 C MRS spectra were acquired in vitro, demonstrating the feasibility of an eight channel double-tuned transceiver 13 C- 1 H array at 7T.

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