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Abstract #0647

Age-Related Changes in Total Cerebral and Cardiac Blood Flow in Children and Adult Volunteers from 7 months to 60 years

Can Wu 1,2 , Samantha Schoeneman 3 , Amir Honarmand 2 , Susanne Schnell 2 , Michael Markl 1,2 , and Ali Shaibani 2,3

1 Biomedical Engineering, Northwestern University, Chicago, Illinois, United States, 2 Radiology, Northwestern University, Chicago, Illinois, United States, 3 Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States

The purpose of this study was to quantify both cerebral arterial inflow using 4D flow and cardiac outflow with 2D phase-contrast MRI and investigate the age dependence of changes in total cerebral arterial flow in relation to aortic flow in a cohort of 40 normal subjects with ages from 7 months to 60 years. The results demonstrated age-related changes in both cerebral and aortic blood flow as well as changes in their relationship, indicating the importance of age-controlled control groups for the detection of abnormal hemodynamics in neurovascular diseases (e.g. cerebral arteriovenous malformations, vein of Galen malformations, intracranial atherosclerotic disease).

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