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Abstract #0651

Longitudinal relationship between amyloid burden and cerebrovascular health in healthy individuals: a combined MRI and PET study

Peiying Liu 1 , Karen Rodrigue 2 , Kristen Kennedy 2 , Shin-Lei Peng 1 , Yang Li 1 , Michael Devous 3 , Denise Park 2 , and Hanzhang Lu 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Center for Vital Longevity, University of Texas at Dallas, Texas, United States, 3 Avid Radiopharmaceuticals Inc, Texas, United States

Accumulation of lower case Greek beta -amyloid (A lower case Greek beta ) protein in the brain is a key process in the pathogenesis of Alzheimers disease, but the relationship between A lower case Greek beta and vascular function in normal controls is unclear. In this work, we conducted a longitudinal study in healthy individuals at two time points 4-year apart. We found that A lower case Greek beta accumulation in the brain has a negative impact on cerebrovascular reactivity, and A lower case Greek beta accumulation may be the cause of cerebrovascular degeneration. We also found a positive correlation between Wave 1 A lower case Greek beta and Wave 2 CBF, suggesting neural compensatory processes may be present that result in elevated blood flow.

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