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Abstract #0650

Correlation of brain atrophy to decreased CBF and CVR in coronary artery disease patients.

Udunna Anazodo 1,2 , Kevin Shoemaker 3 , Neville Suskin 4 , Danny JJ Wang 5 , and Keith S St Lawrence 1,2

1 Lawson Health Research Institute, London, Ontario, Canada, 2 Medical Biophysics, Western University, London, Ontario, Canada, 3 School of Kinesiology, Western University, London, Ontario, Canada, 4 London Health Sciences Cardiology Rehabilitation Program, London, Ontario, Canada, 5 University of California, Los Angeles, California, United States

The impact of cardiovascular disease on brain structure and function is not well known. In this study we present evidence of cortical thinning and cerebral hypoperfusion in brains of coronary artery disease patients including area often associated with cognitive function. Correlation of brain atrophy to hypoperfusion and decreased vascular dynamics, measured with cerebrovascular reactivity suggest that vascular disease can accelerate decline in brain structure and function.

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