Abstract #0661
Application of native myocardial T1 mapping in subjects with coronary microvascular dysfunction and no obstructive coronary artery disease
Jaime L. Shaw 1,2 , Janet Wei 3 , Puja K. Mehta 3 , David Chen 1 , Michael Nelson 1,3 , Louise E.J. Thomson 3 , Daniel S. Berman 3 , C. Noel Bairey Merz 3 , Debiao Li 1,2 , and Behzad Sharif 1
1
Biomedical Imaging Research Institute,
Cedars-Sinai Medical Center, Los Angeles, CA, United
States,
2
Department
of Bioengineering, University of California, Los
Angeles, Los Angeles, CA, United States,
3
Cedars-Sinai
Heart Institute, Los Angeles, CA, United States
Abnormally elevated myocardial native T1 values are
known to suggest diffuse myocardial fibrosis. In this
study, we hypothesized that native myocardial T1 would
be abnormally elevated in subjects with signs and
symptoms of ischemia, no obstructive coronary artery
disease (CAD), and suspected coronary microvascular
dysfunction (CMD). We measured myocardial native T1 in
symptomatic women with no obstructed CAD enrolled in a
single-site cohort of the NHLBI-sponsored WISE-Coronary
Vascular Dysfunction study. Relative to published normal
native T1 values, native T1 values in women with signs
and symptoms of ischemia and no obstructive CAD were
significantly elevated.
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