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Abstract #0662

Black-Blood Contrast-Enhanced MRI: Validation of a Novel Technique for the Diagnosis of Myocardial Infarction

Han W Kim 1 , Wolfgang G Rehwald 2 , David C Wendell 1 , Elizabeth R Jenista 1 , Lowie Van Assche 1 , Christoph Jensen 1 , Peter Filev 1 , Enn-Ling Chen 1 , Michele A Parker 1 , and Raymond J Kim 1

1 Cardiology/Medicine, Duke Cardiovascular Magnetic Resonance Center, Duke University Medical Center, Durham, NC, United States, 2 Siemens Healthcare, NC, United States

PURPOSE. Flow-Independent Dark-blood DeLayed-Enhancement (FIDDLE) allows visualization of tissue contrast-enhancement with blood-pool suppression. METHODS. We validated FIDDLE in a canine model of myocardial infarction (MI) and demonstrated feasibility in patients. FIDDLE and standard delayed-enhancement-MRI (DE-MRI) were compared to histopathology (animals) and the infarct-related-artery by cath (patients). RESULTS. FIDDLE black-blood images were successfully obtained in all animals and patients, and provided improved accuracy for the diagnosis of MI compared with DE-MRI. CONCLUSIONS. We have developed a novel technique that provides tissue contrast-enhancement simultaneous with blood-suppression. Validation and feasibility is demonstrated for diagnosis of MI; additional applications are expected beyond cardiac imaging.

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