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Abstract #0678

Noninvasive assessment of lymphatic impairment and interstitial protein accumulation using chemical exchange saturation transfer (CEST) MRI

Manus Donahue 1,2 , Paula CM Donahue 3,4 , Swati Rane 1 , Megan K Strother 1 , Allison O Scott 1 , and Seth A Smith 1

1 Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 2 Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, 3 Physical Medicine and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN, United States, 4 Dayani Center for Health and Wellness, Nashville, TN, United States

The overall goal of this work is to apply a custom CEST imaging approach to patients with, or at risk for, breast cancer treatment-related lymphedema (BCRL) to assess interstitial protein accumulation and lymphatic compromise. Elevated interstitial protein accumulation is a hallmark for lymphatic failure; results of this study support the ability of APT CEST to provide contrast consistent with lateralizing disease in patients with breast cancer treatment-related lymphedema, thereby motivating the further investigation of these and similar methods for evaluating lymphatic dysfunction.

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