Abstract #0678
Noninvasive assessment of lymphatic impairment and interstitial protein accumulation using chemical exchange saturation transfer (CEST) MRI
Manus Donahue 1,2 , Paula CM Donahue 3,4 , Swati Rane 1 , Megan K Strother 1 , Allison O Scott 1 , and Seth A Smith 1
1
Radiology and Radiological Sciences,
Vanderbilt University Medical Center, Nashville, TN,
United States,
2
Physics
and Astronomy, Vanderbilt University, Nashville, TN,
United States,
3
Physical
Medicine and Rehabilitation, Vanderbilt University
Medical Center, Nashville, TN, United States,
4
Dayani
Center for Health and Wellness, Nashville, TN, United
States
The overall goal of this work is to apply a custom CEST
imaging approach to patients with, or at risk for,
breast cancer treatment-related lymphedema (BCRL) to
assess interstitial protein accumulation and lymphatic
compromise. Elevated interstitial protein accumulation
is a hallmark for lymphatic failure; results of this
study support the ability of APT CEST to provide
contrast consistent with lateralizing disease in
patients with breast cancer treatment-related
lymphedema, thereby motivating the further investigation
of these and similar methods for evaluating lymphatic
dysfunction.
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