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Abstract #0681

Regional and age-related variations of the healthy spinal cord structure assessed by multimodal MRI (diffusion, inhomogeneous magnetization transfer, ihMT)

Manuel Taso 1,2 , Olivier M. Girard 3,4 , Guillaume Duhamel 3,4 , Arnaud Le Troter 3,4 , Guilherme Ribeiro 3,4 , Thorsten Feiweier 5 , Maxime Guye 3,4 , Jean-Philippe Ranjeva 3,4 , and Virginie Callot 3,4

1 CRMBM-CEMEREM UMR 7339, Aix-Marseille Universit, CNRS, Marseille, France, 2 LBA UMR T 24, Aix-Marseille Universit, IFSTTAR, Marseille, France, 3 CRMBM UMR 7339, Aix-Marseille Universit, CNRS, Marseille, France, 4 CEMEREM, Pole d'imagerie mdicale, Hopital la TImone, AP-HM, Marseille, France, 5 Siemens AG, Healthcare, Erlangen, Germany

MRI can provide valuable information about spinal cord (SC) structure. In the current study, we combine multimodal MRI (DTI and inhomogeneous magnetization transfer, ihMT) and atlas-based analysis of the derived parametric data to study: 1) healthy internal SC structural variations (in terms of myelin and axonal content at different levels) and 2) impairment occurring through the lifespan. Thereby, we highlighted vertebral level and sensory/motor tract-specific SC structure dependency, as well as demyelination and axonal loss occurring with age. Altogether, this study also provides a normative DTI and MT/ihMT database metrics at different ages, useful for pathological studies (MS, ALS).

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