Abstract #0682
Validation of MRI microstructure measurements with Coherent Anti-Stokes Raman Scattering (CARS)
Tanguy Duval 1 , Alicja Gasecka 2,3 , Philippe Pouliot 1,4 , Daniel Ct 2,3 , Nikola Stikov 1,5 , and Julien Cohen-Adad 1,6
1
Institute of Biomedical Engineering,
Polytechnique Montral, Montral, Qc, Canada,
2
Quebec
Mental Health University Institute, Qubec, Qc, Canada,
3
Doptic,
photonic and laser Center, Universit Laval, Qubec, Qc,
Canada,
4
Montreal
Heart Institute, Montreal, Quebec, Canada,
5
Montreal
Neuronal Institute, McGill University, Montral, Qubec,
Canada,
6
Functional
Neuroimaging Unit, CRIUGM, Universit de Montral,
Montral, Qc, Canada
Histology is considered to be the gold standard for
validating quantitative MRI techniques. However, common
histology techniques can induce biases due to the tissue
preparation (fixation, cutting and staining), rendering
challenging the validation of quantitative MRI
biomarkers. Recently, a large-scale microscopy technique
called Coherent Anti-Stokes Raman Scattering (CARS) was
introduced, enabling (i) sub-micrometer resolution, (ii)
in-depth focus preventing artifacts related to
non-perfectly flat tissue surface and (iii) specific
contrast to myelin without the need for staining. Here
we applied the CARS technique to validate AxCaliber
experiments for estimating axon diameter measurements.
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