Abstract #0683
Diffusion MRI reveals tissue specific changes in early and late stages of degeneration within the spinal cord
Torben Schneider 1 , Gemma Nejati-Gilani 2,3 , Mohamed Tachrount 4 , Ying Li 5 , Amber Hill 4 , Olga Ciccarelli 4 , Ken Smith 6 , David Thomas 7 , Daniel C Alexander 3 , and Claudia A M Wheeler-Kingshott 1
1
NMR Research Unit, Department of
Neuroinflammation, Queen Square MS Centre, UCL Institute
of Neurology, London, United Kingdom,
2
Department
of Infectious Disease Epidemiology, Imperial College,
London, United Kingdom,
3
Centre
for Medical Image Computing, Department of Computer
Science, University College London, London, United
Kingdom,
4
Brain
Repair & Rehabilitation, UCL Institute of Neurology,
London, United Kingdom,
5
Spinal
Repair Unit, Brain Repair & Rehabilitation, UCL
Institute of Neurology, London, United Kingdom,
6
Department
of Neuroinflammation, Queen Square MS Centre, UCL
Institute of Neurology, London, United Kingdom,
7
Leonard
Wolfson Experimental Neurology Centre, UCL Institute of
Neurology, London, United Kingdom
Diffusion MRI has been applied successfully before to
study rodent models of spinal cord damage, but no
attempt has been made to try to explicitly model the
different pathological effects in the damaged white
matter. This study demonstrates the application of a
complex diffusion MRI model to early and late axonal
injury. We find that axon radius, together with changes
in diffusivity and compartmentalisation are
discriminating best between early and late stage changes
in spinal cord lesion and replicate independent measures
of axonal damage in histology.
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