Abstract #0684
Longitudinal characterization of the Wallerian degeneration process by a multi-compartment diffusion model: DIAMOND after a rhizotomy in the rat spinal cord and comparison with the histology
Damien Jacobs 1 , Benoit Scherrer 2 , Aleksandar Jankovski 3 , Anne des Rieux 4 , Maxime Taquet 1 , Bernard Gallez 4 , Simon K. Warfield 2 , and Benoit Macq 1
1
ICTEAM, Universite catholique de Louvain,
Louvain-La-Neuve, Belgium,
2
Computational
Radiology Laboratory, Boston Childrens Hospital,
Massachusetts, United States,
3
Hopital
universitaire Mont-Godinne, Universite catholique de
Louvain, Godinne, Belgium,
4
LDRI,
Universite catholique de Louvain, Brussels, Belgium
The aim of this study is to investigate the Wallerian
degeneration process by DIAMOND, a multi-compartment
diffusion model, in the rat spinal cord after a
rhizotomy. With a longitudinal imaging approach and
several histological observations for each specific
cellular response, the fluctuations of the diffusion
parameters are analyzed and compared to the Wallerian
degeneration process in the course of time.
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