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Abstract #0684

Longitudinal characterization of the Wallerian degeneration process by a multi-compartment diffusion model: DIAMOND after a rhizotomy in the rat spinal cord and comparison with the histology

Damien Jacobs 1 , Benoit Scherrer 2 , Aleksandar Jankovski 3 , Anne des Rieux 4 , Maxime Taquet 1 , Bernard Gallez 4 , Simon K. Warfield 2 , and Benoit Macq 1

1 ICTEAM, Universite catholique de Louvain, Louvain-La-Neuve, Belgium, 2 Computational Radiology Laboratory, Boston Childrens Hospital, Massachusetts, United States, 3 Hopital universitaire Mont-Godinne, Universite catholique de Louvain, Godinne, Belgium, 4 LDRI, Universite catholique de Louvain, Brussels, Belgium

The aim of this study is to investigate the Wallerian degeneration process by DIAMOND, a multi-compartment diffusion model, in the rat spinal cord after a rhizotomy. With a longitudinal imaging approach and several histological observations for each specific cellular response, the fluctuations of the diffusion parameters are analyzed and compared to the Wallerian degeneration process in the course of time.

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