Abstract #0685
Diffusion Basis Spectrum Imaging quantifies pathologies in Cervical Spondylotic Myelopathy
Peng Sun 1 , Rory Murphy 2 , Yong Wang 1 , Joanne Wagner 3 , Sammir Sullivan 1 , Paul Gamble 2 , Kim Griffin 1,2 , Wilson Z. Ray 2 , and Sheng-Kwei Song 1
1
Radiology, Washington University in St.
Louis, St. Louis, MO, United States,
2
Neurosurgery,
Washington University in St. Louis, St. Louis, MO,
United States,
3
Physical
Therapy and Athletic Training, Saint Louis University,
St. Louis, MO, United States
Cervical spondylotic myelopathy (CSM) is the most common
form of spinal cord injury, but no effective diagnostic
approach available to accurately reflect underlying
tissue damage. In this study, newly developed diffusion
basis spectrum imaging (DBSI) was applied to quantify
pathologies in CSM. DBSI successfully delineated axon
and myelin injury, quantified the extent of axon loss
and edema of CSM spinal cord. Findings suggest that axon
loss may be the primary contributor to neurological
impairment in CSM. The multiple metrics derived by DBSI,
could offer an insight to the underlying pathologies
responsible for the evolving neurological impairments in
CSM.
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