Abstract #0686
Evaluating the Feasibility of Monitoring In Vivo Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging
Ilwoo Park 1 , Jason F. Talbott 1,2 , and Sarah J. Nelson 1,3
1
Department of Radiology and Biomedical
Imaging, University of California San Francisco, San
Francisco, CA, United States,
2
Brain
and Spine Injury Center (BASIC), San Francisco General
Hospital, San Francisco, CA, United States,
3
Department
of Bioengineering and Therapeutic Sciences, University
of California San Francisco, CA, United States
This study has demonstrated the feasibility of using
hyperpolarized
13
C
MR imaging with [1-
13
C]pyruvate for
evaluating in vivo metabolism of spinal cord. High
pyruvate and relatively small lactate signal were
observed in the cervical spinal cord of uninjured rats.
The results from this study suggest that this technique
may provide a unique non-invasive imaging tool that is
able to monitor biochemical processes underlying spinal
cord injury.
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