Abstract #0692
Dual Iron/Fluorine Cell Tracking: Monitoring the Fate of Human Stem Cells and the ensuing Cellular Inflammatory Response
Jeff M Gaudet 1,2 , Matthew S Fox 1 , Amanda M Hamilton 1 , and Paula J Foster 1,2
1
Imaging Research Laboratories, Robarts
Research Institute, London, Ontario, Canada,
2
Medical
Biophysics, Western University, London, Ontario, Canada
Mesenchymal Stem Cells (MSC) are currently being
investigated as a candidate for clinical trials. In this
study we investigate a novel technique for imaging both
the implanted stem cells, along with the inflammatory
response
in
vivo
using
dual iron/fluorine MRI agents. MSC were labeled
in
vitro
with
19
F
prior to implantation and phagocytic immune cells were
labeled
in
situ
with
intravenous (IV) iron. Quantification of
19
F-MRI
on day 0 agrees with the expected number of cells.
Following IV administration of iron, signal voids were
observed at the site of implantation in the proton
images and the
19
F
signal drops significantly.
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