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Abstract #0692

Dual Iron/Fluorine Cell Tracking: Monitoring the Fate of Human Stem Cells and the ensuing Cellular Inflammatory Response

Jeff M Gaudet 1,2 , Matthew S Fox 1 , Amanda M Hamilton 1 , and Paula J Foster 1,2

1 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada, 2 Medical Biophysics, Western University, London, Ontario, Canada

Mesenchymal Stem Cells (MSC) are currently being investigated as a candidate for clinical trials. In this study we investigate a novel technique for imaging both the implanted stem cells, along with the inflammatory response in vivo using dual iron/fluorine MRI agents. MSC were labeled in vitro with 19 F prior to implantation and phagocytic immune cells were labeled in situ with intravenous (IV) iron. Quantification of 19 F-MRI on day 0 agrees with the expected number of cells. Following IV administration of iron, signal voids were observed at the site of implantation in the proton images and the 19 F signal drops significantly.

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