Abstract #0691
In vivo monitoring of immune cell kinetics with time-lapse MRI in the ischemic lesion of mouse brain
Yuki Mori 1,2 , Ting Chen 1,2 , and Yoshichika Yoshioka 1,2
1
Biofunctional Imaging, Immunology Frontier
Research Center (IFReC), Osaka University, Suita, Osaka,
Japan,
2
Center
for Information and Neural Networks, Suita, Osaka, Japan
Combination of MRI and nanoparticles has a possibility
for visualizing the dynamics of cells in mouse brain and
previously we reported the time-lapse movie analysis
have a good feasibility to track the single-cell
migration in mouse brain. In this study, we improve the
temporal resolution of time-lapse MRI movie with SPIO-based
in-situ cell labeling and assess the difference of
velocity and direction of immune cell migration between
the healthy brain and ischemic-injured brain. We showed
that time-lapse MRI has a good possibility to track the
cell migration and assess the difference of cell
kinetics between normal and ischemic lesion.
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