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Abstract #0691

In vivo monitoring of immune cell kinetics with time-lapse MRI in the ischemic lesion of mouse brain

Yuki Mori 1,2 , Ting Chen 1,2 , and Yoshichika Yoshioka 1,2

1 Biofunctional Imaging, Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan, 2 Center for Information and Neural Networks, Suita, Osaka, Japan

Combination of MRI and nanoparticles has a possibility for visualizing the dynamics of cells in mouse brain and previously we reported the time-lapse movie analysis have a good feasibility to track the single-cell migration in mouse brain. In this study, we improve the temporal resolution of time-lapse MRI movie with SPIO-based in-situ cell labeling and assess the difference of velocity and direction of immune cell migration between the healthy brain and ischemic-injured brain. We showed that time-lapse MRI has a good possibility to track the cell migration and assess the difference of cell kinetics between normal and ischemic lesion.

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