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Abstract #0694

Using SWIFT T1 mapping to quantify iron oxide nanoparticles uptake and biodistribution in organs in-vivo

Jinjin Zhang 1 , Hattie L. Ring 1,2 , Katie Hurley 2 , Qi Shao 3 , Nathan D. Klein 2 , Christy Haynes 2 , John Bischof 4 , and Michael Garwood 1

1 Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2 Department of Chemistry, University of Minnesota, MN, United States, 3 Department of Biomedical Engineering, University of Minnesota, MN, United States, 4 Department of Mechanical Engineering, University of Minnesota, MN, United States

The positive contrast due to T1-shortening from SPIO nanoparticles created by SWIFT sequence was applied to quantify in-vivo biodistribution of SPIONs in major organs of mouse at concentrations up to 2 mg Fe/ml (=35 mM), which is more than one order of magnitude higher than was previously reported. SPIONs were delivered intravenously. The average R1 of liver and kidney post-injection both showed linear dependence on the iron concentration in corresponding organ measured by ICP-MS. SWIFT T1 mapping is a promising tool to assess SPIONs uptake, biodistribution and clearance processes in major organs for nanoparticle-based thermal therapy or drug delivery systems.

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