Abstract #0694
Using SWIFT T1 mapping to quantify iron oxide nanoparticles uptake and biodistribution in organs in-vivo
Jinjin Zhang 1 , Hattie L. Ring 1,2 , Katie Hurley 2 , Qi Shao 3 , Nathan D. Klein 2 , Christy Haynes 2 , John Bischof 4 , and Michael Garwood 1
1
Center for Magnetic Resonance Research,
Department of Radiology, University of Minnesota,
Minneapolis, MN, United States,
2
Department
of Chemistry, University of Minnesota, MN, United
States,
3
Department
of Biomedical Engineering, University of Minnesota, MN,
United States,
4
Department
of Mechanical Engineering, University of Minnesota, MN,
United States
The positive contrast due to T1-shortening from SPIO
nanoparticles created by SWIFT sequence was applied to
quantify in-vivo biodistribution of SPIONs in major
organs of mouse at concentrations up to 2 mg Fe/ml (=35
mM), which is more than one order of magnitude higher
than was previously reported. SPIONs were delivered
intravenously. The average R1 of liver and kidney
post-injection both showed linear dependence on the iron
concentration in corresponding organ measured by ICP-MS.
SWIFT T1 mapping is a promising tool to assess SPIONs
uptake, biodistribution and clearance processes in major
organs for nanoparticle-based thermal therapy or drug
delivery systems.
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