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Abstract #0695

Sensing the high magnetic field: Fusion of otoliths in zebrafish larvae entails a hint

Patricia Pais Roldn 1 , Ajeet Singh 1 , Hellmut Merkle 1 , Hildegard Schulz 1 , and Xin Yu 1

1 Max Planck Institute, Tuebingen, Baden-Wuerttemberg, Germany

Here we described the impact of the high magnetic field (MF) on zebrafish larvae aiming to identify potential biological MR sensors. 14T-MF exposures longer than 2 hours in zebrafish larvae led to fusion of 2 otoliths (CaCO3 crystals in the inner ear responsible for balance and hearing) and a subsequent aberrant balance behavior, a phenotype already described in genetic mutants. Identification of the cellular and molecular mechanisms underlying this MF-induced otolith-fusion may be tackled with a zebrafish mutagenesis approach and might contribute in an efficient way to search for MR sensors in biological models.

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