Abstract #0695
Sensing the high magnetic field: Fusion of otoliths in zebrafish larvae entails a hint
Patricia Pais Roldn 1 , Ajeet Singh 1 , Hellmut Merkle 1 , Hildegard Schulz 1 , and Xin Yu 1
1
Max Planck Institute, Tuebingen,
Baden-Wuerttemberg, Germany
Here we described the impact of the high magnetic field
(MF) on zebrafish larvae aiming to identify potential
biological MR sensors. 14T-MF exposures longer than 2
hours in zebrafish larvae led to fusion of 2 otoliths
(CaCO3 crystals in the inner ear responsible for balance
and hearing) and a subsequent aberrant balance behavior,
a phenotype already described in genetic mutants.
Identification of the cellular and molecular mechanisms
underlying this MF-induced otolith-fusion may be tackled
with a zebrafish mutagenesis approach and might
contribute in an efficient way to search for MR sensors
in biological models.
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