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Abstract #0696

Genetically functionalized magnetosomes as MRI contrast agent suitable for molecular imaging

Marianne Boucher 1 , Nicolas Ginet 2 , Franoise Geffroy 1 , Sandra Prveral 2 , Graldine Adryanczyk-Perrier 2 , Michel Pean 2 , Christopher T Lefvre 2 , Daniel Garcia 2 , David Pignol 2 , and Sbastien Mriaux 1

1 UNIRS, CEA/DSV/I2BM/NeuroSpin, Saclay, France, 2 LBC, CEA/DSV/IBEB/SBVME, Saint-Paul-lez-Durance, France

Magnetosomes are iron nanocrystals embedded in a lipid bilayer which are produced by magnetotactic bacteria. We propose to demonstrate the efficiency of magnetosomes as T 2 contrast agent for MRI, and the feasibility of harvesting functionalized magnetosomes from genetically modified bacteria. RGD peptide, known for targeting α ν β 3 integrins, has been chosen for functionalization and the affinity of targeting magnetosomes is demonstrated with U87 cells. The contrasting properties of magnetosomes are assessed by acquiring T 2 *w images prior and after injection and comparing number of detected hypointense voxels. Thus, magnetosomes possess MRI sensitivity and α ν β 3 specificity required for future molecular imaging experiments.

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