Meeting Banner
Abstract #0697

Structural-Physiological Relationships in the Visual System upon Glutamate Excitotoxicity in the Eye using Diffusion Tensor Imaging and Manganese-enhanced MRI

Leon C. Ho 1,2 , Bo Wang 3,4 , Ian P. Conner 3,4 , Yolandi van der Merwe 1,4 , Richard A. Bilonick 3 , Ed X. Wu 2 , Seong-Gi Kim 1,5 , Gadi Wollstein 3 , Joel S. Schuman 3,4 , and Kevin C. Chan 1,3

1 Neuroimaging Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, China, 3 Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 4 Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 5 Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, Korea

Excitotoxicity has been linked to the pathogenesis of ocular diseases and injuries and may involve early degeneration of both anterior and posterior visual pathways. To date, the spatiotemporal patterns of neurodegeneration in the visual system and the relationships with excitotoxic retinal injury and optic neuropathy are not fully elucidated. In this study, we employed DTI and MEMRI to study the microstructural alterations, anterograde Mn transport and their correlations along the visual pathway upon N-methyl-D-aspartate (NMDA)-induced glutamate excitotoxicity in the eye, in order to determine the pathophysiological events and structural-physiological relationships in the injured visual pathways.

This abstract and the presentation materials are available to members only; a login is required.

Join Here