Abstract #0698
MEMRI detects neuronal activity and connectivity in hypothalamic neural circuit.
Anna Ulyanova 1 , Judy Chia Ghee Sng 2 , Weiping Han 3 , and Kai-Hsiang Chuang 1
1
Magnetic Resonance Imaging Group, Singapore
Bioimaging Consortium, A*STAR, Singapore, Singapore,
Singapore,
2
Department
of Pharmacology, National University of Singapore,
Singapore, Singapore, Singapore,
3
Lab
of metabolic Medicine, Singapore Bioimaging Consortium,
A*STAR, Singapore, Singapore, Singapore
Manganese-Enhanced MRI (MEMRI) has been used to detect
brain connectivity and activity in vivo. MEMRI signal
depends on various factors affecting Mn2+ uptake and
transport. To what extent MEMRI can reflect neuronal
activity is still uncertain. We evaluated whether MEMRI
signal in different hypothalamic nuclei represents Ca2+
activity by Ca2+ channel blockade, axonal transport by
microtubule disruption, and neural activity by c-Fos
expression. We have confirmed MEMRI can be used for
mapping certain but not all activated neuronal pathway
in hypothalamus. These findings can facilitate the
interpretation of hypothalamic neurocircuit network in
responding to nutritional and hormonal signals using
MEMRI.
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