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Abstract #0698

MEMRI detects neuronal activity and connectivity in hypothalamic neural circuit.

Anna Ulyanova 1 , Judy Chia Ghee Sng 2 , Weiping Han 3 , and Kai-Hsiang Chuang 1

1 Magnetic Resonance Imaging Group, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore, Singapore, 2 Department of Pharmacology, National University of Singapore, Singapore, Singapore, Singapore, 3 Lab of metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, Singapore, Singapore, Singapore

Manganese-Enhanced MRI (MEMRI) has been used to detect brain connectivity and activity in vivo. MEMRI signal depends on various factors affecting Mn2+ uptake and transport. To what extent MEMRI can reflect neuronal activity is still uncertain. We evaluated whether MEMRI signal in different hypothalamic nuclei represents Ca2+ activity by Ca2+ channel blockade, axonal transport by microtubule disruption, and neural activity by c-Fos expression. We have confirmed MEMRI can be used for mapping certain but not all activated neuronal pathway in hypothalamus. These findings can facilitate the interpretation of hypothalamic neurocircuit network in responding to nutritional and hormonal signals using MEMRI.

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