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Abstract #0699

Manganese PET enables the same contrast as Manganese Enhanced MRI

Galit Saar 1 , Corina M. Millo 2 , Lawrence P. Szajek 2 , Jeff Bacon 2 , Peter Herscovitch 2 , and Alan P. Koretsky 1

1 LFMI/NINDS, NIH, Bethesda, MD, United States, 2 PET Department, Clinical Center, NIH, Bethesda, MD, United States

Manganese has been used as a functional contrast agent in many pre-clinical MRI studies. However, Mn 2+ cellular toxicity limits its use as contrast agent in humans to low concentrations. We studied 51 Mn (t1/2=46.2min) and 52 Mn (t1/2=5.6days) for PET imaging in rats and monkeys. We show that manganese radiotracers give similar contrast to Mn 2+ in MRI with accumulation in different tissues following systemic infusion even at the low concentration used. 52 Mn-PET can trace olfactory pathways in the brain following intranasal administration in monkey, similar to MEMRI in rodents. Manganese PET should allow using the unique properties of Mn in clinical studies.

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