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Abstract #0714

Detection of Diffuse Myocardial Fibrosis In Vivo Using Diffusion Tensor Imaging with the Supertoroidal Model

Choukri Mekkaoui 1 , Howard H Chen 2 , Yin-Ching Iris Chen 2 , William J Kostis 2 , Marcel P Jackowski 3 , Timothy G Reese 2 , and David E Sosnovik 2

1 Harvard Medical School - Massachussetts General Hospital, Boston, MA, United States, 2 Harvard Medical School-Massachusetts General Hospital, Boston, MA, United States, 3 University of So Paulo, So Paulo, Brazil

Left ventricular hypertrophy (LVH) is accompanied by a diffuse pattern of myocardial fibrosis. The ability of conventional DTI metrics to detect diffuse fibrosis, however, remains unclear. Here we show that the toroidal volume (TV), derived from the supertoroidal model of the diffusion tensor, provides a sensitive metric of local diffusivity. DTI was performed in mice with LVH due to aortic banding. Despite the presence of marked fibrosis, mean diffusivity (MD) and fractional anisotropy (FA) remained normal. In contrast, TV was significantly reduced in the banded mice, demonstrating its sensitivity and the value of the supertoroidal model in detecting microstructural changes.

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