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Abstract #0718

Whole-heart T2-mapping at 7T quantifies dystrophic myocardial pathology in mdx/utrn+/- mice

Ronald John Beyers 1 , Christopher Ballmann 2 , Joshua Selsby 3 , Nouha Salibi 1,4 , John Quindry 2 , and Thomas S Denney 1

1 MRI Research Center, Auburn University, Auburn University, AL, United States, 2 Kinesiology, Auburn University, Auburn University, AL, United States, 3 Department of Animal Science, Iowa State University, Ames, IA, United States, 4 MR R&D, Siemens Healthcare, Malvern, PA, United States

Duchenne muscular dystrophy (DMD) causes cardiac dysfunction. In a DMD mice model, we developed and applied cardiac MR as whole-heart T2-mapping sequence to quantify myocardial T2 changes and to confirm that quercetin treatment is cardio-protective in DMD mice with haploinsufficiency of the utrophin gene (mdx/utrn+/-). T2 mapping confirmed significantly higher T2 in untreated mdx/utrn+/- hearts, but normal T2 in quercetin treated hearts at age 10 months. T2-mapping in mice hearts is effective for tracking T2 changes. Quercetin treatment helps protect from DMD cardiac dysfunction.

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