Abstract #0718
Whole-heart T2-mapping at 7T quantifies dystrophic myocardial pathology in mdx/utrn+/- mice
Ronald John Beyers 1 , Christopher Ballmann 2 , Joshua Selsby 3 , Nouha Salibi 1,4 , John Quindry 2 , and Thomas S Denney 1
1
MRI Research Center, Auburn University,
Auburn University, AL, United States,
2
Kinesiology,
Auburn University, Auburn University, AL, United States,
3
Department
of Animal Science, Iowa State University, Ames, IA,
United States,
4
MR
R&D, Siemens Healthcare, Malvern, PA, United States
Duchenne muscular dystrophy (DMD) causes cardiac
dysfunction. In a DMD mice model, we developed and
applied cardiac MR as whole-heart T2-mapping sequence to
quantify myocardial T2 changes and to confirm that
quercetin treatment is cardio-protective in DMD mice
with haploinsufficiency of the utrophin gene
(mdx/utrn+/-). T2 mapping confirmed significantly higher
T2 in untreated mdx/utrn+/- hearts, but normal T2 in
quercetin treated hearts at age 10 months. T2-mapping in
mice hearts is effective for tracking T2 changes.
Quercetin treatment helps protect from DMD cardiac
dysfunction.
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