Meeting Banner
Abstract #0721

Heritability of structural connections from HCP diffusion MRI data

Stamatios N Sotiropoulos 1 , Xu Chen 2 , Stephen M Smith 1 , David C Van Essen 3 , Timothy E Behrens 1 , Thomas E Nichols 2 , and Saad Jbabdi 1

1 FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2 Department of Statistics, University of Warwick, Coventry, United Kingdom, 3 Department of Anatomy & Neurobiology, Washington University, St Louis, MO, United States

There is great interest in understanding population variability of brain connectivity patterns, and the genetic contributions to this variability. Heritability, the proportion of variability attributable to genetic sources, is a quantitative measure that allows the identification of phenotypes. In this work, we examine the heritability of structural connections using diffusion MRI data from the HCP. We compute whole-brain structural connectivity matrices and infer on heritability using permutation testing. Importantly, we localise regions with most heritable connections across different cortical parcellations and compare to heritability trends of cortical morphological features.

This abstract and the presentation materials are available to members only; a login is required.

Join Here