Abstract #0722
Motor and non-motor territories of the human dentate nucleus: Mapping the topographical connectivity of the cerebellar cortex with in-vivo sub-millimeter diffusion imaging
Christopher J. Steele 1 , Alfred Anwander 1 , Pierre-Louis Bazin 1 , Robert Trampel 1 , Andreas Schaefer 1 , Robert Turner 1 , Narender Ramnani 2 , and Arno Villringer 1
1
Max Planck Institute for Human Cognitive and
Brain Sciences, Leipzig, Sachsen, Germany,
2
Royal
Holloway University of London, Egham, Surrey, United
Kingdom
The cortico-cerebellar loops form one of the largest
systems in the brain, yet we have virtually no knowledge
about cerebellar anatomical connectivity in humans. We
acquired sub-mm cerebellar diffusion images and applied
highly specific tractography to understand the
cortico-cerebellar loops and provide insight on the
influence of motor and non-motor dentate nucleus
territories on the brain. We found the first structural
evidence that the human dentate nucleus contains a
motor/non-motor topographical organisation and,
crucially, present novel evidence that the relative
influence of non-motor functions of the cerebellum may
have increased relative to that of our primate cousins.
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