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Abstract #0722

Motor and non-motor territories of the human dentate nucleus: Mapping the topographical connectivity of the cerebellar cortex with in-vivo sub-millimeter diffusion imaging

Christopher J. Steele 1 , Alfred Anwander 1 , Pierre-Louis Bazin 1 , Robert Trampel 1 , Andreas Schaefer 1 , Robert Turner 1 , Narender Ramnani 2 , and Arno Villringer 1

1 Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Sachsen, Germany, 2 Royal Holloway University of London, Egham, Surrey, United Kingdom

The cortico-cerebellar loops form one of the largest systems in the brain, yet we have virtually no knowledge about cerebellar anatomical connectivity in humans. We acquired sub-mm cerebellar diffusion images and applied highly specific tractography to understand the cortico-cerebellar loops and provide insight on the influence of motor and non-motor dentate nucleus territories on the brain. We found the first structural evidence that the human dentate nucleus contains a motor/non-motor topographical organisation and, crucially, present novel evidence that the relative influence of non-motor functions of the cerebellum may have increased relative to that of our primate cousins.

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