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Abstract #0728

Stretched-exponential model DWI (SEM-DWI) as a potential imaging biomarker in grading gliomas and assessment of proliferative activity

Jingjing Jiang 1 and Wenzhen Zhu 1

1 Tongji hospital, tongji medical college, huazhong university of science and technology, Wuhan, Hubei, China

Diffusion wighted imaging (DWI) is one of the advanced neuroimaging techniques in the evaluation of brain tumors. Stretched exponential model DWI (SEM-DWI) is one of them which can properly describe the signal intensity decay when b-factor exceeds 1000 s/mm2. Proliferating cell nuclear antigen (PCNA) and Ki-67 are two of the common nuclear markers in proliferation activity evaluation. In this study, we will assess the feasibility of SEM-DWI in grading gliomas and to find the correlation between DWI parameters and PCNA and Ki-67 labeling index (LI) thus to evaluate DWI as a noninvasive technique for evaluating the proliferative characteristics of gliomas.

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